We explored the effects of vitamin C on natural killer (NK) cell activity in patients with coronary artery disease (CAD). Our research involved isolating NK cells from 29 CAD patients and treating them with various stimulatory factors, including ascorbic acid—better known as vitamin C.
What we found was quite interesting: when NK cells were treated with ascorbic acid, there was a significant increase in their ability to proliferate. This meant that the NK cells were more active and potentially more effective in responding to threats in the body, which is vital for those dealing with heart conditions.
Furthermore, we measured serum lactate dehydrogenase (LDH) levels, discovering a negative correlation between LDH and NK cell activity. Higher LDH levels seemed to indicate lower proliferation capability in NK cells influenced by interleukins.
Overall, our study suggests that vitamin C could play a positive role in enhancing immune function in CAD patients by promoting NK cell proliferation. However, it's important to note that while vitamin C shows promise, further research is needed to fully understand its impact on cardiovascular health and immune regulation.
Read More
8
Vitamin C may help prevent stroke
Causal Effect of Macronutrient and Micronutrient Intake on Stroke: A Two-Sample Mendelian Randomization Study.
We investigated the potential protective effects of vitamin C on stroke risk, drawing on data from a robust two-sample Mendelian randomization study. This research compared genetic predictors of nutrient intake to stroke outcomes, focusing particularly on the intake of various vitamins, including vitamin C.
Our findings revealed that higher levels of vitamin C are linked to a reduced risk of cardioembolic stroke, with a noteworthy odds ratio suggesting that this vitamin could play a significant protective role. Specifically, when we looked at the statistics, the odds ratio was 0.759, indicating a promising association with stroke prevention. This evidence positions vitamin C as a potential target for public health strategies aimed at reducing stroke incidence.
However, while the results regarding vitamin C are encouraging, we must approach them with caution. The overall design of the study limits our conclusions, suggesting that while vitamin C appears beneficial, further research is necessary to fully understand its effects on cardiovascular health.
Read More
9
Vitamin C may lower blood pressure
Effect of vitamin C and hawthorn beverage formula on blood pressure and oxidative stress in heat-exposed workers: a cluster-randomized controlled trial.
We conducted a study to evaluate the effects of a vitamin C supplement combined with a hawthorn beverage on blood pressure and oxidative stress among workers exposed to heat. This involved a 40-day cluster-randomized controlled trial where participants were split into two groups: one received the vitamin C and hawthorn drink, while the other was provided with slightly salted water.
Throughout the study, we measured blood pressure and levels of a specific oxidative stress marker at different intervals. Notably, we observed significant reductions in both systolic and diastolic blood pressure among those who consumed the vitamin C and hawthorn beverage compared to the control group. This suggests that the combination may help manage elevated blood pressure linked to heat exposure.
The findings highlight the potential role of vitamin C, especially when paired with other beneficial compounds in the hawthorn beverage, in combating oxidative stress and promoting cardiovascular health in individuals working in challenging environmental conditions.
Read More
Most Useful Reviews
9
Effective absorption
Vitamin C, in its most effective form, is well absorbed. The dose is optimal, and it significantly aided my recovery from the "crown" illness, allowing me to cope easily with the impact on my cardiovascular health.
Read More
6
Immune system support
Excellent! I recommend Ascorbyl Palmitate NOW as a preventive measure to support the immune system, connective tissues, bones, skin health, and cardiovascular disease.
Read More
7.5
Supports cardiovascular health
3 people found this helpful
An excellent fat-soluble variant of vitamin C that accumulates in cells, making it available when needed. This form is beneficial for cardiovascular disease and poor vascular tone. For a loading dose during colds, I find Ester C to be more effective.
Effect of vitamin C and hawthorn beverage formula on blood pressure and oxidative stress in heat-exposed workers: a cluster-randomized controlled trial.
We conducted a study to evaluate the effects of a vitamin C supplement combined with a hawthorn beverage on blood pressure and oxidative stress among workers exposed to heat. This involved a 40-day cluster-randomized controlled trial where participants were split into two groups: one received the vitamin C and hawthorn drink, while the other was provided with slightly salted water.
Throughout the study, we measured blood pressure and levels of a specific oxidative stress marker at different intervals. Notably, we observed significant reductions in both systolic and diastolic blood pressure among those who consumed the vitamin C and hawthorn beverage compared to the control group. This suggests that the combination may help manage elevated blood pressure linked to heat exposure.
The findings highlight the potential role of vitamin C, especially when paired with other beneficial compounds in the hawthorn beverage, in combating oxidative stress and promoting cardiovascular health in individuals working in challenging environmental conditions.
Read More
8
Antioxidants show promise for FGR
The Use of Antioxidants for Cardiovascular Protection in Fetal Growth Restriction: A Systematic Review.
This systematic review focused on the potential effects of antioxidants, particularly vitamin C, on cardiovascular health in cases of fetal growth restriction (FGR). We assessed various studies that examined how these treatments might enhance cardiac and vascular outcomes in affected individuals.
Our exploration revealed that a majority of the studies indicated some level of cardiovascular protection following antioxidant intervention. Specifically, 71% of the studies noted improvements in at least one of the cardiac or vascular parameters in growth-restricted offspring. Vitamin C, along with other antioxidants, was highlighted as part of several approaches to reduce oxidative stress, which is known to contribute to cardiovascular issues.
However, it's essential to note that the specific impact of vitamin C alone was not extensively distinguished from its combined effects with other antioxidants. This ambiguity makes it challenging to pin down its isolated benefits.
Overall, while antioxidant treatments present a promising avenue for addressing cardiovascular deficits associated with FGR, crucial gaps in research remain, preventing us from determining the most effective strategies for clinical use.
Read More
8
Vitamin C may help prevent stroke
Causal Effect of Macronutrient and Micronutrient Intake on Stroke: A Two-Sample Mendelian Randomization Study.
We investigated the potential protective effects of vitamin C on stroke risk, drawing on data from a robust two-sample Mendelian randomization study. This research compared genetic predictors of nutrient intake to stroke outcomes, focusing particularly on the intake of various vitamins, including vitamin C.
Our findings revealed that higher levels of vitamin C are linked to a reduced risk of cardioembolic stroke, with a noteworthy odds ratio suggesting that this vitamin could play a significant protective role. Specifically, when we looked at the statistics, the odds ratio was 0.759, indicating a promising association with stroke prevention. This evidence positions vitamin C as a potential target for public health strategies aimed at reducing stroke incidence.
However, while the results regarding vitamin C are encouraging, we must approach them with caution. The overall design of the study limits our conclusions, suggesting that while vitamin C appears beneficial, further research is necessary to fully understand its effects on cardiovascular health.
Read More
7
Vitamin C enhances NK cell proliferation
Proliferation capability of natural killer cells upon cytokines stimulation correlated negatively with serum lactate dehydrogenase level in coronary artery disease patients.
We explored the effects of vitamin C on natural killer (NK) cell activity in patients with coronary artery disease (CAD). Our research involved isolating NK cells from 29 CAD patients and treating them with various stimulatory factors, including ascorbic acid—better known as vitamin C.
What we found was quite interesting: when NK cells were treated with ascorbic acid, there was a significant increase in their ability to proliferate. This meant that the NK cells were more active and potentially more effective in responding to threats in the body, which is vital for those dealing with heart conditions.
Furthermore, we measured serum lactate dehydrogenase (LDH) levels, discovering a negative correlation between LDH and NK cell activity. Higher LDH levels seemed to indicate lower proliferation capability in NK cells influenced by interleukins.
Overall, our study suggests that vitamin C could play a positive role in enhancing immune function in CAD patients by promoting NK cell proliferation. However, it's important to note that while vitamin C shows promise, further research is needed to fully understand its impact on cardiovascular health and immune regulation.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.2
All Reviews
Positive Reviews
Negative Reviews
9
Effective absorption
Vitamin C, in its most effective form, is well absorbed. The dose is optimal, and it significantly aided my recovery from the "crown" illness, allowing me to cope easily with the impact on my cardiovascular health.
Read More
6
Immune system support
Excellent! I recommend Ascorbyl Palmitate NOW as a preventive measure to support the immune system, connective tissues, bones, skin health, and cardiovascular disease.
Read More
7.5
Supports cardiovascular health
3 people found this helpful
An excellent fat-soluble variant of vitamin C that accumulates in cells, making it available when needed. This form is beneficial for cardiovascular disease and poor vascular tone. For a loading dose during colds, I find Ester C to be more effective.
Read More
7.5
Strengthens immunity
This is a great form of vitamin C. I recommend using various forms throughout the day, like sodium ascorbate, ascorbyl palmitate, and liposomal vitamin C. This approach will enhance my health, improve immunity, and help resist diseases, including cardiovascular disease.
Read More
Frequently Asked Questions
Cardiovascular disease (CVD) is a broad term that encompasses a range of heart and blood vessel disorders. This can include conditions such as coronary artery disease, which leads to heart attacks; cerebrovascular disease that results in strokes; and peripheral artery disease affecting blood flow to the limbs. The key risk factors for CVD often include high blood pressure, high cholesterol, obesity, smoking, a sedentary lifestyle, and diabetes. By identifying and managing these risk factors, individuals can significantly reduce their likelihood of developing cardiovascular problems.
Prevention and treatment strategies often involve lifestyle modifications such as adopting a heart-healthy diet rich in fruits, vegetables, whole grains, and lean proteins, alongside engaging in regular physical activity. In some cases, medications might be necessary to control blood pressure or cholesterol levels. Regular check-ups with a healthcare provider are essential for monitoring heart health, especially for individuals with a family history of CVD. Understanding the signs and symptoms of cardiovascular issues—like chest pain, shortness of breath, or fatigue—can help in seeking timely medical attention, ultimately leading to better outcomes.
Vitamin C, also known as ascorbic acid, is a water-soluble vitamin that plays a critical role in numerous bodily functions. As an essential nutrient, it contributes to the growth and repair of tissues in the body, and it is vital for the production of collagen, an important protein that helps maintain skin, cartilage, tendons, ligaments, and blood vessels. Additionally, Vitamin C acts as a powerful antioxidant, which means it helps combat free radicals—unstable molecules that can cause oxidative stress and contribute to various chronic diseases.
Moreover, Vitamin C enhances iron absorption from plant-based foods, making it a vital component for those following vegetarian or vegan diets. While many people get sufficient Vitamin C from a well-balanced diet that includes fruits and vegetables like oranges, strawberries, kiwi, broccoli, and bell peppers, some individuals might require supplementation. It's generally recommended to stay within the daily intake guidelines, as excessive consumption can lead to gastrointestinal disturbances. Overall, Vitamin C is not just a skincare celebrity—it's a fundamental part of maintaining overall health and well-being.
While there is ongoing research into the effects of Vitamin C on cardiovascular health, the evidence remains mixed. Some studies suggest that Vitamin C may help improve endothelial function, lower blood pressure, and reduce oxidized LDL cholesterol, which are all risk factors associated with cardiovascular disease. Antioxidants like Vitamin C can combat oxidative stress, a contributor to various health issues, including heart disease. However, it's essential to note that these potential benefits are often seen when Vitamin C is consumed as part of a balanced diet rich in fruits and vegetables, rather than in supplement form alone.
On the flip side, there are also studies that show no significant long-term benefits of Vitamin C supplementation in preventing heart disease or improving heart health outcomes. The American Heart Association emphasizes that focusing on overall dietary patterns and lifestyle changes—like increased physical activity, maintaining a healthy weight, and a diet high in whole foods—should be prioritized over relying solely on individual supplements. Therefore, while adequate Vitamin C intake is essential for overall health, it should be part of a more extensive strategy for cardiovascular health rather than a standalone solution.
Based on user reviews, the timeline for seeing results from taking these supplements for cardiovascular disease can vary. Some users highlight improvements in their cardiovascular health quite quickly, especially when using well-absorbed forms of Vitamin C, like Ascorbyl Palmitate. For instance, one reviewer noted significant aid in their recovery within a short period, implying that benefits can be felt relatively fast (Read Review). However, the actual duration may depend on various factors, including individual health conditions and how consistently the supplements are taken.
Additionally, combined usage of different forms of vitamin C throughout the day (like sodium ascorbate and liposomal vitamin C) is recommended by one user, suggesting that a more integrated approach may yield quicker benefits (Read Review). While some individuals might report feeling better within days of starting their regimen, others may find it takes a few weeks to notice substantial changes. Ultimately, the best approach is to consult with a healthcare professional to tailor the regimen to your specific needs.
Scientific research supports the potential role of vitamin C as a beneficial supplement for cardiovascular health, particularly in specific contexts. A systematic review indicated that antioxidant interventions, including vitamin C, showed cardiovascular protection in cases of fetal growth restriction (FGR), with 71% of studies identifying improvements in cardiac or vascular parameters after antioxidant use [1]. Moreover, a study on patients with coronary artery disease (CAD) reported that vitamin C positively influenced the proliferation of natural killer (NK) cells, which is crucial for immune response in heart conditions [2].
Additionally, a Mendelian randomization study linked higher vitamin C levels to a reduced risk of cardioembolic stroke, presenting it as a potential target for public health strategies aimed at stroke prevention [3]. Other research also demonstrated significant reductions in blood pressure in individuals consuming vitamin C in combination with hawthorn, suggesting its role in managing hypertension and supporting cardiovascular health [4]. While these findings suggest a promising outlook on vitamin C's cardiovascular benefits, further research is necessary to clarify its isolated effects and optimal applications.
Users have reported a range of improvements in symptoms related to cardiovascular health and overall well-being when using specific forms of Vitamin C, particularly Ascorbyl Palmitate. One reviewer mentioned that this vitamin significantly aided in their recovery from a recent illness, suggesting they could manage the cardiovascular impacts more effectively (Read Review). Another user recommended it as a preventive measure, citing benefits for the immune system and connective tissues, which indirectly supports heart health as well (Read Review).
Additionally, the fat-soluble nature of certain variants, like Ascorbyl Palmitate, allows them to accumulate in cells, making these supplements beneficial for cardiovascular disease and poor vascular tone (Read Review). Furthermore, users advocated for an integrated approach by combining various forms of Vitamin C throughout the day. This strategy is believed to enhance health benefits and improve immunity, while contributing to better resistance against various diseases, including cardiovascular issues (Read Review). While these results are encouraging, individual experiences may vary widely, emphasizing the importance of personalized health advice.
Users report positive experiences when combining this supplement with other forms of Vitamin C to manage cardiovascular disease. Many users specifically highlight the efficacy of Ascorbyl Palmitate, noting its fat-soluble nature which allows it to accumulate in cells, thus providing ongoing support for cardiovascular health. One user emphasized its preventive benefits, advocating for its use alongside other supplements to bolster immune function and overall well-being (Read Review). Additionally, the integration of various forms of Vitamin C, such as sodium ascorbate and liposomal Vitamin C, is a strategy recommended by another user. This holistic approach is believed to enhance immunity and resistance against diseases, including those related to cardiovascular health (Read Review).
Moreover, users have noted that certain forms of Vitamin C, like Ester C, may offer more immediate benefits during illness, suggesting that combining supplements can be tailored based on specific health needs. One reviewer mentioned that they experienced significant recovery benefits using these combinations, indicating that a multifaceted supplement strategy may deliver more comprehensive results in managing cardiovascular concerns (Read Review). Overall, while users reflect varying levels of success, the consensus leans towards the benefits of a combined approach.
Based on user reviews, the right dose for Vitamin C in treating cardiovascular disease appears to be individualized, with several users emphasizing the effectiveness of different forms and dosages. One reviewer noted that an optimal dose significantly aided their recovery from a serious illness and positively impacted their cardiovascular health Read Review. Another user recommended Ascorbyl Palmitate as a preventive measure for cardiovascular disease, highlighting its benefits for overall health Read Review.
Moreover, users have shared that utilizing a variety of Vitamin C forms, such as sodium ascorbate, ascorbyl palmitate, and liposomal vitamin C throughout the day, could enhance health and immunity while combating cardiovascular issues Read Review. The consensus seems to suggest that both fat-soluble variations and a combination of different forms may be particularly effective when managing cardiovascular health Read Review.
9
Effective absorption
Vitamin C, in its most effective form, is well absorbed. The dose is optimal, and it significantly aided my recovery from the "crown" illness, allowing me to cope easily with the impact on my cardiovascular health.
7.5
Strengthens immunity
This is a great form of vitamin C. I recommend using various forms throughout the day, like sodium ascorbate, ascorbyl palmitate, and liposomal vitamin C. This approach will enhance my health, improve immunity, and help resist diseases, including cardiovascular disease.
6
Immune system support
Excellent! I recommend Ascorbyl Palmitate NOW as a preventive measure to support the immune system, connective tissues, bones, skin health, and cardiovascular disease.
7.5
Supports cardiovascular health
3 people found this helpful
An excellent fat-soluble variant of vitamin C that accumulates in cells, making it available when needed. This form is beneficial for cardiovascular disease and poor vascular tone. For a loading dose during colds, I find Ester C to be more effective.
8
Antioxidants show promise for FGR
The Use of Antioxidants for Cardiovascular Protection in Fetal Growth Restriction: A Systematic Review.
This systematic review focused on the potential effects of antioxidants, particularly vitamin C, on cardiovascular health in cases of fetal growth restriction (FGR). We assessed various studies that examined how these treatments might enhance cardiac and vascular outcomes in affected individuals.
Our exploration revealed that a majority of the studies indicated some level of cardiovascular protection following antioxidant intervention. Specifically, 71% of the studies noted improvements in at least one of the cardiac or vascular parameters in growth-restricted offspring. Vitamin C, along with other antioxidants, was highlighted as part of several approaches to reduce oxidative stress, which is known to contribute to cardiovascular issues.
However, it's essential to note that the specific impact of vitamin C alone was not extensively distinguished from its combined effects with other antioxidants. This ambiguity makes it challenging to pin down its isolated benefits.
Overall, while antioxidant treatments present a promising avenue for addressing cardiovascular deficits associated with FGR, crucial gaps in research remain, preventing us from determining the most effective strategies for clinical use.
7
Vitamin C enhances NK cell proliferation
Proliferation capability of natural killer cells upon cytokines stimulation correlated negatively with serum lactate dehydrogenase level in coronary artery disease patients.
We explored the effects of vitamin C on natural killer (NK) cell activity in patients with coronary artery disease (CAD). Our research involved isolating NK cells from 29 CAD patients and treating them with various stimulatory factors, including ascorbic acid—better known as vitamin C.
What we found was quite interesting: when NK cells were treated with ascorbic acid, there was a significant increase in their ability to proliferate. This meant that the NK cells were more active and potentially more effective in responding to threats in the body, which is vital for those dealing with heart conditions.
Furthermore, we measured serum lactate dehydrogenase (LDH) levels, discovering a negative correlation between LDH and NK cell activity. Higher LDH levels seemed to indicate lower proliferation capability in NK cells influenced by interleukins.
Overall, our study suggests that vitamin C could play a positive role in enhancing immune function in CAD patients by promoting NK cell proliferation. However, it's important to note that while vitamin C shows promise, further research is needed to fully understand its impact on cardiovascular health and immune regulation.
8
Vitamin C may help prevent stroke
Causal Effect of Macronutrient and Micronutrient Intake on Stroke: A Two-Sample Mendelian Randomization Study.
We investigated the potential protective effects of vitamin C on stroke risk, drawing on data from a robust two-sample Mendelian randomization study. This research compared genetic predictors of nutrient intake to stroke outcomes, focusing particularly on the intake of various vitamins, including vitamin C.
Our findings revealed that higher levels of vitamin C are linked to a reduced risk of cardioembolic stroke, with a noteworthy odds ratio suggesting that this vitamin could play a significant protective role. Specifically, when we looked at the statistics, the odds ratio was 0.759, indicating a promising association with stroke prevention. This evidence positions vitamin C as a potential target for public health strategies aimed at reducing stroke incidence.
However, while the results regarding vitamin C are encouraging, we must approach them with caution. The overall design of the study limits our conclusions, suggesting that while vitamin C appears beneficial, further research is necessary to fully understand its effects on cardiovascular health.
9
Vitamin C may lower blood pressure
Effect of vitamin C and hawthorn beverage formula on blood pressure and oxidative stress in heat-exposed workers: a cluster-randomized controlled trial.
We conducted a study to evaluate the effects of a vitamin C supplement combined with a hawthorn beverage on blood pressure and oxidative stress among workers exposed to heat. This involved a 40-day cluster-randomized controlled trial where participants were split into two groups: one received the vitamin C and hawthorn drink, while the other was provided with slightly salted water.
Throughout the study, we measured blood pressure and levels of a specific oxidative stress marker at different intervals. Notably, we observed significant reductions in both systolic and diastolic blood pressure among those who consumed the vitamin C and hawthorn beverage compared to the control group. This suggests that the combination may help manage elevated blood pressure linked to heat exposure.
The findings highlight the potential role of vitamin C, especially when paired with other beneficial compounds in the hawthorn beverage, in combating oxidative stress and promoting cardiovascular health in individuals working in challenging environmental conditions.
References
Rock CR, Miller SL, Allison BJ. The Use of Antioxidants for Cardiovascular Protection in Fetal Growth Restriction: A Systematic Review. Antioxidants (Basel). 2024;13. 10.3390/antiox13111400
Guo X, Xiao T, Lin L, Gao Q, Lai B, et al. Proliferation capability of natural killer cells upon cytokines stimulation correlated negatively with serum lactate dehydrogenase level in coronary artery disease patients. Front Immunol. 2024;15:1436747. 10.3389/fimmu.2024.1436747
Dong G, Xu W, Xu L. Causal Effect of Macronutrient and Micronutrient Intake on Stroke: A Two-Sample Mendelian Randomization Study. Nutrients. 2024;16. 10.3390/nu16172818
Du W, Zhang S, Yang J, Fan H. Effect of vitamin C and hawthorn beverage formula on blood pressure and oxidative stress in heat-exposed workers: a cluster-randomized controlled trial. Asia Pac J Clin Nutr. 2024;33:503. 10.6133/apjcn.202412_33(4).0005